Tomilov A F, Podivilova T N
Ter Arkh. 1990;62(4):108-11.
A study was made of bone marrow smears (17 puncture specimens) in 10 patients with systemic mastocytosis (SMC). The amount of mast cells (MC) in the myelograms widely ranged (from single cells to 39.6%) and in some cases, it was less than in healthy persons or in patients with other diseases. A semiquantitative method is suggested for estimating the population of MC which were distributed into four groups according to the degree of saturation with metachromatic granules. 1769 MC were estimated: from 61 to 200 in each specimen. In the control group (8 specimens from patients with leukemias and aplasias), 638 MC were estimated. The cytochemical coefficient (CCC) in SMC appeared to be equal to M +/- m = 1.34 +/- 0.11/M +/- 1.5 sigma = 0.6-2.1 l/, in the control group, it was 3.0 +/- 0.1/M +/- 1.5 sigma = 2.6-3.4/; p less than 0.001. The CCC less than or equal to 2.1 is considered to be one of the criteria for the diagnosis of SMC.
对10例系统性肥大细胞增多症（SMC）患者的骨髓涂片（17份穿刺标本）进行了研究。骨髓象中肥大细胞（MC）的数量差异很大（从单个细胞到39.6%），在某些情况下，其数量低于健康人或其他疾病患者。建议采用一种半定量方法来评估MC的数量，根据异染颗粒的饱和程度将MC分为四组。共评估了1769个MC：每个标本中有61至200个。在对照组（8份白血病和再生障碍性贫血患者的标本）中，评估了638个MC。SMC中的细胞化学系数（CCC）似乎等于M +/- m = 1.34 +/- 0.11/M +/- 1.5 sigma = 0.6 - 2.1 l/，对照组中为3.0 +/- 0.1/M +/- 1.5 sigma = 2.6 - 3.4/；p < 0.001。CCC小于或等于2.1被认为是诊断SMC的标准之一。
