School of Human Ecology, Nutrition and Dietetics Program, Louisiana Tech University, Ruston, LA, USA.
Nutrition. 2013 Sep;29(9):1115-21. doi: 10.1016/j.nut.2013.02.014.
The objective of this study was to investigate the effects of the interaction between lipoprotein lipase (LPL) PvuII and HindIII haplotypes and carbohydrate intakes on the components of metabolic syndrome (MetSyn) in Koreans.
LPL PvuII and HindIII genotype, LPL mass, triglyceride, high-density lipoprotein cholesterol, blood pressure (BP), waist circumference (WC), insulin, and Homeostasis Model of Assessment - Insulin Resistance were determined using a cross-sectional design in 269 controls and 280 MetSyn patients.
LPL mass was significantly lower in patients with PvuII and HindIII mutant alleles (P2 and H2) and decreased as the number of MetSyn components increased in all PvuII and HindIII haplotypes. Both LPL mass-adjusted WC and systolic BP (SBP) were positively associated with a ratio of percent energy from carbohydrate to percent energy from fat in individuals with P2H2 haplotype. After adjustment for age, sex, and LPL mass, the odds ratio (OR) for excessive WC was higher in carriers of P2H2 in the highest carbohydrate intake tertile compared with carriers of P1H1 in the lowest carbohydrate intake tertile (OR, 6.94; 95% confidence interval [CI], 1.39-34.62). Moreover, the OR for high SBP were higher in carriers of P1H2/P2H1 in the highest carbohydrate intake tertile (OR, 7.84; 95% CI, 1.79-34.46) and in carriers of P2H2 in the highest carbohydrate intake tertile (OR, 4.24; 95% CI, 1.16-15.48) than P1H1 carriers.
This study suggests that P2H2 carriers in the highest carbohydrate intake tertile may be at risk for MetSyn because they had increased odds of excessive WC and high SBP.
本研究旨在探讨脂蛋白脂肪酶（LPL）PvuII 和 HindIII 单倍型与碳水化合物摄入之间的相互作用对韩国人代谢综合征（MetSyn）各组分的影响。
采用横断面设计，对 269 例对照者和 280 例 MetSyn 患者进行了 LPL PvuII 和 HindIII 基因型、LPL 质量、甘油三酯、高密度脂蛋白胆固醇、血压（BP）、腰围（WC）、胰岛素和稳态模型评估-胰岛素抵抗的检测。
PvuII 和 HindIII 突变等位基因（P2 和 H2）携带者的 LPL 质量显著降低，且在所有 PvuII 和 HindIII 单倍型中，随着 MetSyn 成分数量的增加，LPL 质量逐渐降低。在 P2H2 单倍型个体中，LPL 质量调整后的 WC 和收缩压（SBP）与碳水化合物能量百分比与脂肪能量百分比之比呈正相关。在校正年龄、性别和 LPL 质量后，与碳水化合物摄入最低三分位组的 P1H1 携带者相比，碳水化合物摄入最高三分位组的 P2H2 携带者的 WC 异常比值比（OR）更高（OR，6.94；95%可信区间[CI]，1.39-34.62）。此外，碳水化合物摄入最高三分位组的 P1H2/P2H1 携带者和 P2H2 携带者的高 SBP 的 OR 更高（OR，7.84；95% CI，1.79-34.46 和 OR，4.24；95% CI，1.16-15.48）比 P1H1 携带者。
本研究表明，碳水化合物摄入最高三分位组的 P2H2 携带者可能有发生 MetSyn 的风险，因为他们发生 WC 异常和 SBP 升高的比值更高。
