Moeller T
Institut für Pflanzenschutzforschung der Akademie der Landwirtschaftswissenschaften der DDR.
Z Gesamte Hyg. 1990 Jun;36(6):314-6.
Mecoprop caused in former toxicological examinations time and dose dependent changes of structural components of the immune system. By investigation of humoral and cell immunity was to test, if functional parameter are also influenced by the substance. Mecoprop decreased the delayed hypersensitivity as parameter of cell immunity. The haemagglutination titer against sheep erythrocytes was not influenced by the substance. But the decrease of IgG-concentration in the serum shows also an effect of Mecoprop on the humoral immunity. Adrenalectomy was carried out to test, if there is an indirect mechanism of the action on the immune system, which is mediated by the activity of adrenals. The results show a nearly complete elimination of substance effects in adrenalectomized animals.
在之前的毒理学检查中，2甲4氯导致免疫系统结构成分出现时间和剂量依赖性变化。通过对体液免疫和细胞免疫的研究，来测试功能参数是否也受该物质影响。2甲4氯降低了作为细胞免疫参数的迟发型超敏反应。针对绵羊红细胞的血凝滴度不受该物质影响。但血清中IgG浓度的降低也表明2甲4氯对体液免疫有作用。进行肾上腺切除术以测试是否存在由肾上腺活动介导的对免疫系统的间接作用机制。结果显示，在肾上腺切除的动物中，该物质的影响几乎完全消除。
