Finkenwirth C, Roßbach B, Schröder H C, Muttray A
1Institute for Physiological Chemistry, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany.
Hum Exp Toxicol. 2014 May;33(5):517-21. doi: 10.1177/0960327113499164. Epub 2013 Aug 8.
In this randomized parallel study, we examined whether an acute ozone (O3) exposure leads to increased DNA strand breaks in human lymphocytes. The groups were exposed to 0.21 ppm O3 or filtered air for two hours. 30min and 4.5 h after exposure, DNA damage was determined in isolated lymphocytes using the Fast Micromethod. There was no detectable effect after O3 exposure. We conclude that an acute O3 exposure at the tested concentration does not lead to persistent DNA damage.
在这项随机平行研究中，我们检测了急性臭氧（O3）暴露是否会导致人类淋巴细胞中DNA链断裂增加。将各实验组暴露于0.21 ppm的O3或过滤空气中两小时。暴露后30分钟和4.5小时，使用快速微量法测定分离淋巴细胞中的DNA损伤。臭氧暴露后未检测到影响。我们得出结论，在测试浓度下的急性臭氧暴露不会导致持续性DNA损伤。
