通过应用β-取代丙烯酸盐的自由基环化反应来接近海洋前列腺素的官能化环戊烷核心。
Approach to the functionalized cyclopentane core of marine prostanoids by applying a radical cyclization of β-disubstituted acrylates.
机构信息
Australian Research Council Centre of Excellence for Free Radical Chemistry and Biotechnology, Australia.
出版信息
Org Biomol Chem. 2013 Sep 28;11(36):6186-94. doi: 10.1039/c3ob41263f.
PMID:23928860
Abstract
A synthetic approach to highly functionalized cyclopentanes that incorporate adjacent secondary and tertiary alcohols is described. These systems, prepared in one step by a ketyl radical cyclization of β-disubstituted acrylates, represent the core of the marine prostanoid family of natural products.
摘要
本文描述了一种高度官能化的环戊烷的合成方法，其中包含相邻的仲醇和叔醇。这些系统通过β-取代丙烯酸盐的酮基自由基环化一步制备，是海洋前列腺素类天然产物家族的核心。
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