Department of Medicine, Robarts Research Institute, Western University, London, Ontario, Canada.
Inflamm Bowel Dis. 2013 Sep;19(10):2223-6. doi: 10.1097/MIB.0b013e31829b3e1d.
: Although the incidence of Clostridium difficile-associated diarrhea in the general population has increased dramatically over the past decade, an even greater rate of infection exists in patients with inflammatory bowel disease. Susceptibility in this population is likely inherent to the pathophysiology and treatment of these diseases. C. difficile infection can cause serious complications and death. Consequently, early diagnosis and initiation of effective antibacterial therapy is imperative. This article evaluates treatment recommendations for an initial episode of C. difficile infection in patients with inflammatory bowel disease based on the current guidelines and a Cochrane systematic review.
虽然过去十年中，普通人群中艰难梭菌相关性腹泻的发病率显著增加，但炎症性肠病患者的感染率更高。该人群的易感性可能与这些疾病的病理生理学和治疗有关。艰难梭菌感染可导致严重并发症和死亡。因此，早期诊断和开始有效的抗菌治疗至关重要。本文根据当前指南和 Cochrane 系统评价，评估了炎症性肠病患者初次艰难梭菌感染的治疗建议。
