Dosis T J, Thevoz F, Fisher D L, Adatepe M H, Merkow P, Magovern G J
J Thorac Cardiovasc Surg. 1975 Aug;70(2):229-36.
The preliminary results and the technique of total reversal of the pulmonary circulation (RPC) are presented. Total RPC is technically feasible and not incompatible with life. It affords a new experimental model for in vivo study of pulmonary pathophysiology. The influence of this reversal on blood oxygenation, on pulmonary vascular resistance, and on established pulmonary hypertension, as well as its reaction to hypoxia and acidosis, needs further investigation. RPC may have clinical implications in essential pulmonary hypertension and congenital pulmonary vascular anomalies.
本文介绍了肺循环完全逆转（RPC）的初步结果和技术。完全RPC在技术上是可行的，且与生命不相容。它为肺病理生理学的体内研究提供了一种新的实验模型。这种逆转对血液氧合、肺血管阻力和已确立的肺动脉高压的影响，以及其对缺氧和酸中毒的反应，需要进一步研究。RPC可能对特发性肺动脉高压和先天性肺血管异常具有临床意义。
