Human Reproduction and Genetics Center, Department of Gynecology and Obstetrics, Faculdade de Medicina do ABC, Santo André/SP, Brazil.
Obesity (Silver Spring). 2014 Mar;22(3):939-42. doi: 10.1002/oby.20590. Epub 2013 Sep 23.
To determine differences in follicle stimulation, oocyte retrieval, maturation, and fertilization among patients who underwent bariatric surgery, obese patients, and patients with 18 < BMI < 30 kg/m² submitted to assisted reproduction techniques and check that these patients may have some impairment in ovarian response.
The study comprised three groups: GI: 29 patients who had undergone restrictive and/or malabsorptive bariatric surgery; GII: 57 obese patients (BMI > 30 kg/m²); and GIII: 94 patients (18 < BMI < 30 kg/m²) with infertility due to a male factor. BMI, weight loss until oocyte retrieval, vitamin supplementation, and anemia were evaluated. Data were compared with the number of follicles observed, the number of oocytes retrieved, and the maturation status of these oocytes. Results were analyzed statistically.
A statistically significant difference in the number of follicles observed by ultrasound (P < 0.01), the number of oocytes retrieved (P = 0.013), and the number of metaphase II oocytes (P < 0.01) between the patients with prior bariatric surgery and both GII and GIII group was found.
The weight loss resulting from bariatric surgery can be very beneficial to the overall health of the woman, but the reproductive process can be impaired. Bariatric surgery appears to have an important impact on the formation of follicles and oocytes.
确定接受减重手术、肥胖症患者和 BMI 为 18<30kg/m²的接受辅助生殖技术的不孕患者之间的卵泡刺激、卵母细胞采集、成熟和受精差异，并检查这些患者的卵巢反应可能存在一些损害。
该研究包括三组：GI 组：29 例接受限制和/或吸收不良减重手术的患者；GII 组：57 例肥胖症患者（BMI>30kg/m²）；GIII 组：94 例因男性因素导致不孕的患者（18<BMI<30kg/m²）。评估 BMI、卵母细胞采集前的体重减轻、维生素补充和贫血情况。比较观察到的卵泡数量、采集的卵母细胞数量以及这些卵母细胞的成熟状态。结果进行了统计学分析。
发现有减重手术史的患者与 GII 组和 GIII 组相比，超声观察到的卵泡数量（P<0.01）、采集的卵母细胞数量（P=0.013）和中期 II 卵母细胞数量（P<0.01）存在统计学显著差异。
减重手术导致的体重减轻对女性的整体健康非常有益，但生殖过程可能会受损。减重手术似乎对卵泡和卵母细胞的形成有重要影响。
