T 细胞受体的基因工程：TCR 转向肌联蛋白。
Genetic engineering of T-cell receptors: TCR takes to titin.
机构信息
Baylor College of Medicine.
出版信息
Blood. 2013 Aug 8;122(6):853-4. doi: 10.1182/blood-2013-06-509604.
Abstract
In this issue of Blood, Linette et al report a cautionary tale—a lethal off-target toxicity following T-cell receptor (TCR) optimization to enhance affinity against a tumor-associated antigen, MAGE-A3.
摘要
在本期《Blood》中，Linette 等人报告了一个警示性的故事——一种致命的脱靶毒性，源于 T 细胞受体（TCR）的优化，以增强对肿瘤相关抗原 MAGE-A3 的亲和力。
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