将银用作研究银基抗菌剂生物分布的工具。
The use of Ag as a tool for studying biological distribution of silver-based antimicrobials.
作者信息
Aweda Tolulope A, Ikotun Oluwatayo, Mastren Tara, Cannon Carolyn L, Wright Brian, Youngs Wiley J, Cutler Cathy, Guthrie James, Lapi Suzanne E
机构信息
Mallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis, 510 S. Kingshighway Blvd, St. Louis, MO 63110. ; Tel: 314-362-0284; Tel: 314-367-5537; Tel: 314-362-8154.
出版信息
Medchemcomm. 2013 Jun 1;4(6):1015-1017. doi: 10.1039/C3MD00082F.
Abstract
Recently, there has been an emergence of significant interest in silver-based antimicrobials. Our goal was to develop a radioactive tracer for investigating the biological fate of such compounds. Purified Ag was incorporated into the methylated caffeine analogue, IC1 to yield the silver carbene complex designated as [Ag]SCC1 and investigated in biodistribution studies.
摘要
最近，人们对银基抗菌剂产生了浓厚的兴趣。我们的目标是开发一种放射性示踪剂，用于研究此类化合物的生物归宿。将纯化的银掺入甲基化咖啡因类似物IC1中，得到名为[Ag]SCC1的银卡宾配合物，并在生物分布研究中进行了研究。
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