Alizadeh Farshid, Shahdoost Amir Abbas, Zargham Mahtab, Tadayon Farhad, Joozdani Rasoul Hashemi, Arezegar Hamidreza
Department of Urology, Isfahan University of Medical Sciences, Isfahan, Iran.
Adv Biomed Res. 2013 Mar 6;2:1. doi: 10.4103/2277-9175.107959. Print 2013.
To investigate the effect of polyacrylate polyalcohol copolymer (Vantris) injection for the correction of VUR in children according to ureteral orifice shape and VUR grade.
Forty children (29 girls and 11 boys) with 61 renal refluxing units (RRU) and primary VUR underwent endoscopic correction of their reflux, using Vantris. Under general anesthesia, routine cystoscopy was performed and ureteral orifice configuration and dynamic hydro distention grade were determined. The injection technique was STING, HIT or a combination of them. Ultrasound scan was performed one and 3 months after injection and radionuclide cystography (RNC) was performed 3 months after the operation.
The mean volume of injected Vantris was 0.62 cc. Reflux was corrected in 52 (85.2%) of the 61 RRU after single injection and this equates reflux correction in 37 of the 40 patients. No significant correlation was observed between ureteral orifice shape and VUR correction rate.
Our results showed that there was no correlation between the ureteral orifice configuration and the success rate of endoscopic surgery for VUR in short term.
根据输尿管口形状和膀胱输尿管反流（VUR）分级，研究聚丙烯酸多元醇共聚物（Vantris）注射治疗儿童VUR的效果。
40例患有61个肾反流单位（RRU）且为原发性VUR的儿童（29例女孩和11例男孩）接受了使用Vantris的反流内镜矫正术。在全身麻醉下，进行常规膀胱镜检查并确定输尿管口形态和动态水扩张分级。注射技术为STING、HIT或二者结合。注射后1个月和3个月进行超声扫描，术后3个月进行放射性核素膀胱造影（RNC）。
Vantris的平均注射量为0.62立方厘米。单次注射后，61个RRU中的52个（85.2%）反流得到矫正，这相当于40例患者中的37例反流得到矫正。未观察到输尿管口形状与VUR矫正率之间存在显著相关性。
我们的结果表明，短期内输尿管口形态与VUR内镜手术成功率之间无相关性。
