Suppr超能文献

[新一代遗传标记InDel的研究进展]

[Progress in InDel as a new generation of genetic marker].

作者信息

Sun Kuan, Zhang Su-Hua, Zhu Ru-Xin, Zhao Shu-Min, Li Cheng-Tao

机构信息

Department of Forensic Medicine, Shanghai Medical College, Fudan University, Shanghai 200032, China.

出版信息

Fa Yi Xue Za Zhi. 2013 Apr;29(2):134-9, 143.

Abstract

As forensic DNA typing experienced three generations of genetic marker researching stage, short tandem repeat (STR) has been widely used in forensic identification as a mature tool. Further exploration of the human genome led to the discovery of polymorphism markers of single nucleotide polymorphism (SNP) and Insertion/Deletion (InDel). InDel, which combines the desirable characteristics of previous genetic markers as a new type of genetic marker, has got extensive concern in fields like medical molecular biology and forensic biology. This paper generally reviews the history of research and the corresponding results of InDel along the line of time axis as well as the different aims of these research focusing on the progress in the multiple amplification system with several InDel as the genetic marker (autosomal or X chromosome) in forensic biology and anthropology. Finally, the direction of research in this field and the problems to be solved have been put forward.

摘要

随着法医DNA分型经历了三代遗传标记研究阶段,短串联重复序列(STR)作为一种成熟的工具已被广泛应用于法医鉴定。对人类基因组的进一步探索导致了单核苷酸多态性(SNP)和插入/缺失(InDel)多态性标记的发现。InDel作为一种新型遗传标记,兼具了以往遗传标记的理想特性,在医学分子生物学和法医生物学等领域受到了广泛关注。本文沿着时间轴对InDel的研究历史和相应成果进行了综述,同时聚焦于以多个InDel为遗传标记(常染色体或X染色体)的多重扩增系统在法医生物学和人类学中的进展,阐述了这些研究的不同目的。最后,提出了该领域的研究方向和有待解决的问题。

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验