Sun Kuan, Zhang Su-Hua, Zhu Ru-Xin, Zhao Shu-Min, Li Cheng-Tao
Department of Forensic Medicine, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Fa Yi Xue Za Zhi. 2013 Apr;29(2):134-9, 143.
As forensic DNA typing experienced three generations of genetic marker researching stage, short tandem repeat (STR) has been widely used in forensic identification as a mature tool. Further exploration of the human genome led to the discovery of polymorphism markers of single nucleotide polymorphism (SNP) and Insertion/Deletion (InDel). InDel, which combines the desirable characteristics of previous genetic markers as a new type of genetic marker, has got extensive concern in fields like medical molecular biology and forensic biology. This paper generally reviews the history of research and the corresponding results of InDel along the line of time axis as well as the different aims of these research focusing on the progress in the multiple amplification system with several InDel as the genetic marker (autosomal or X chromosome) in forensic biology and anthropology. Finally, the direction of research in this field and the problems to be solved have been put forward.
随着法医DNA分型经历了三代遗传标记研究阶段，短串联重复序列（STR）作为一种成熟的工具已被广泛应用于法医鉴定。对人类基因组的进一步探索导致了单核苷酸多态性（SNP）和插入/缺失（InDel）多态性标记的发现。InDel作为一种新型遗传标记，兼具了以往遗传标记的理想特性，在医学分子生物学和法医生物学等领域受到了广泛关注。本文沿着时间轴对InDel的研究历史和相应成果进行了综述，同时聚焦于以多个InDel为遗传标记（常染色体或X染色体）的多重扩增系统在法医生物学和人类学中的进展，阐述了这些研究的不同目的。最后，提出了该领域的研究方向和有待解决的问题。
