Oliveira Monica S, Duarte Isabelle M, Paiva Amanda V, Yunes Samira N, Almeida Carlos E, Mattos Rita C, Sarcinelli Paula N
Radioprotection and Dosimetry Institute, CNEN, Rio de Janeiro, Brazil.
Arch Environ Occup Health. 2014;69(1):40-5. doi: 10.1080/19338244.2012.719557.
Thorium, cerium, and lanthanum are metals present in several types of minerals, the most common of which is monazite. Cerium and lanthanum are elements in the lanthanides series. Thorium, an actinide metal, is a hazardous element due to its radioactive characteristics. There is a lack of information describing the possible chemical interactions among these elements and the effects they may have on humans. Toxicological analyses were performed using cell viability, cell death, and DNA damage assays. Chemical interactions were evaluated based on the Loewe additivity model. The results indicate that thorium and cerium individually have no toxic effects on lymphocytes. However, thorium associated with lanthanum increases the toxicity of this element, thereby reducing the viability of lymphocytes at low concentrations of metals in the mixture.
钍、铈和镧是存在于几种矿物中的金属，其中最常见的是独居石。铈和镧是镧系元素。钍作为一种锕系金属，因其放射性特征而成为危险元素。目前缺乏关于这些元素之间可能的化学相互作用以及它们对人类可能产生的影响的信息。使用细胞活力、细胞死亡和DNA损伤检测进行了毒理学分析。基于洛维相加模型评估了化学相互作用。结果表明，钍和铈单独对淋巴细胞没有毒性作用。然而，钍与镧结合会增加该元素的毒性，从而在混合物中金属浓度较低时降低淋巴细胞的活力。
