Paiva Amanda V, de Oliveira Monica S, Yunes Samira N, de Oliveira Leonardo G, Cabral-Neto Januário B, de Almeida Carlos Eduardo B
Radiobiology Laboratory, Institute of Radiation Protection and Dosimetry, Brazilian Nuclear Energy Commission (CNEN), SEMEX, Salvador Allende Avenue, s/no., Recreio dos Bandeirantes, Rio de Janeiro 22780-160, RJ, Brazil.
Bull Environ Contam Toxicol. 2009 Apr;82(4):423-7. doi: 10.1007/s00128-008-9596-1. Epub 2008 Nov 1.
Lanthanum (La) is a rare-earth metal with applications in agriculture, industry, and medicine. Since lanthanides show a broad spectrum of applications there is an increased risk of contamination for humans. We examined the effects of lanthanum in Jurkat cells and human peripheral lymphocytes (HPL), and we found that it was cytotoxic and genotoxic on both cell lines. Additionally, HPL were more sensitive to La treatment than Jurkat cells and necrosis was the pathway by which La induced cytotoxicity. Vitamin E was able to diminish the DNA strand breaks induced suggesting that oxidative stress may be involved in the genotoxic process.
镧（La）是一种稀土金属，在农业、工业和医学领域均有应用。由于镧系元素具有广泛的应用，人类面临的污染风险也随之增加。我们研究了镧对Jurkat细胞和人外周血淋巴细胞（HPL）的影响，发现它对这两种细胞系均具有细胞毒性和遗传毒性。此外，HPL对镧处理比Jurkat细胞更敏感，坏死是镧诱导细胞毒性的途径。维生素E能够减少诱导的DNA链断裂，这表明氧化应激可能参与了遗传毒性过程。
