Kara Semra, Ulu-ozkan Hulya, Yilmaz Yavuz, Arikan Fatma Inci, Dilmen Ugur, Bilge Yildiz Dallar
Department of Neonatology, Ankara Training and Research Hospital, Ankara, Turkey.
J Coll Physicians Surg Pak. 2013 Aug;23(8):598-600.
ABO iso-immunization is the most frequent haemolytic disease of the newborn. Treatment depends on the total serum bilirubin level, which may increase very rapidly in the first 48 hours of life in cases of haemolytic disease of the newborn. Phototherapy and, in severe cases, exchange transfusion are used to prevent hyperbilirubinaemic encephalopathy. Intravenous immunoglobulins (IVIG) are used to reduce exchange transfusion. Herein, we present a female newborn who was admitted to the NICU because of ABO immune haemolytic disease. After two courses of 1 g/kg of IVIG infusion, she developed necrotizing enterocolitis (NEC). Administration of IVIG to newborns with significant hyperbilirubinaemia due to ABO haemolytic disease should be cautiously administered and followed for complications.
ABO血型同种免疫是最常见的新生儿溶血病。治疗取决于总血清胆红素水平，在新生儿溶血病的情况下，其在出生后的头48小时内可能会迅速升高。光疗以及在严重病例中进行换血疗法用于预防高胆红素血症性脑病。静脉注射免疫球蛋白（IVIG）用于减少换血。在此，我们报告一名因ABO免疫溶血病入住新生儿重症监护病房的女婴。在输注了两个疗程1 g/kg的IVIG后，她发生了坏死性小肠结肠炎（NEC）。对于因ABO溶血病导致严重高胆红素血症的新生儿，应谨慎使用IVIG并密切关注并发症。
