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两名新生儿静脉输注免疫球蛋白G（IVIG）期间的心律失常：巧合还是有关联？

Cardiac rhythm abnormalities during intravenous immunoglobulin G(IVIG) infusion in two newborn infants: coincidence or association?

作者信息

Tufekci Sinan, Coban Asuman, Bor Meltem, Yasa Beril, Nisli Kemal, Ince Zeynep

机构信息

Division of Neonatology, Department of Pediatrics, Istanbul Medical Faculty, Istanbul University Istanbul, Turkey.

Division of Pediatric Cardiology, Department of Pediatrics, Istanbul Medical Faculty, Istanbul University Istanbul, Turkey.

出版信息

Clin Case Rep. 2015 Sep;3(9):731-4. doi: 10.1002/ccr3.329. Epub 2015 Jul 23.

DOI:10.1002/ccr3.329
PMID:26401276
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4574787/
Abstract

We report the occurrence of supraventricular tachycardia during intravenous immunoglobulin (IVIG) infusion. Supraventricular tachycardia was observed in two newborn patients during IVIG infusion. Both of the babies responded to adenosine treatment. Cardiorespiratory monitoring during IVIG infusion can be recommended because of the possibility of this potentially lifethreatening adverse effect.

摘要

我们报告了静脉注射免疫球蛋白（IVIG）期间发生室上性心动过速的情况。在两名新生儿患者静脉注射IVIG期间观察到室上性心动过速。两名婴儿对腺苷治疗均有反应。鉴于这种潜在的危及生命的不良反应的可能性，建议在IVIG输注期间进行心肺监测。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c77/4574787/1e352d127d6b/ccr30003-0731-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c77/4574787/97aefd7f0cda/ccr30003-0731-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c77/4574787/1e352d127d6b/ccr30003-0731-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c77/4574787/97aefd7f0cda/ccr30003-0731-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c77/4574787/1e352d127d6b/ccr30003-0731-f2.jpg

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本文引用的文献

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Adverse events of intravenous immunoglobulin infusions: a ten-year retrospective study.静脉注射免疫球蛋白输注的不良事件：一项十年回顾性研究。
Asia Pac Allergy. 2013 Oct;3(4):249-56. doi: 10.5415/apallergy.2013.3.4.249. Epub 2013 Oct 31.
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Necrotizing enterocolitis in a newborn following intravenous immunoglobulin treatment for haemolytic disease.静脉注射免疫球蛋白治疗溶血病后新生儿发生坏死性小肠结肠炎。
J Coll Physicians Surg Pak. 2013 Aug;23(8):598-600.
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Adverse effects of human immunoglobulin therapy.人免疫球蛋白治疗的不良反应。
静脉注射免疫球蛋白在胎儿和新生儿中的应用：综述
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The Improvement Effect of Different Doses of Gamma Globulin on the Disease Condition of Infants with Hemolytic Disease of Newborn and Their Effects on Immune Factors in Serum.不同剂量丙种球蛋白对新生儿溶血病患儿病情的改善作用及其对血清免疫因子的影响
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Intravenous immunoglobulin therapy: a snapshot for the internist.静脉注射免疫球蛋白治疗：内科医生的快照。
Intern Emerg Med. 2019 Oct;14(7):1041-1049. doi: 10.1007/s11739-019-02150-z. Epub 2019 Jul 15.
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Adverse Effects of Immunoglobulin Therapy.免疫球蛋白治疗的不良反应。
Front Immunol. 2018 Jun 8;9:1299. doi: 10.3389/fimmu.2018.01299. eCollection 2018.
Transfus Med Rev. 2013 Jul;27(3):171-8. doi: 10.1016/j.tmrv.2013.05.004. Epub 2013 Jul 6.
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Intravenous immunoglobulin: adverse reactions and management.静脉注射免疫球蛋白：不良反应与处理
J Allergy Clin Immunol. 2008 Dec;122(6):1238-9. doi: 10.1016/j.jaci.2008.08.033. Epub 2008 Oct 8.
5
Use of intravenous immunoglobulin in human disease: a review of evidence by members of the Primary Immunodeficiency Committee of the American Academy of Allergy, Asthma and Immunology.静脉注射免疫球蛋白在人类疾病中的应用：美国过敏、哮喘与免疫学会原发性免疫缺陷委员会成员的证据综述
J Allergy Clin Immunol. 2006 Apr;117(4 Suppl):S525-53. doi: 10.1016/j.jaci.2006.01.015.
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Risks associated with the use of intravenous immunoglobulin.
Transfus Med Rev. 2003 Oct;17(4):241-51. doi: 10.1016/s0887-7963(03)00038-5.
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