胆酸类似物控制秀丽隐杆线虫的寿命。
Bile acid look-alike controls life span in C. elegans.
机构信息
Departments of Pediatrics and Laboratory Medicine, University of Groningen, University Medical Center Groningen, The Netherlands.
出版信息
Cell Metab. 2013 Aug 6;18(2):151-2. doi: 10.1016/j.cmet.2013.07.009.
PMID:23931751
Abstract
Extensive transcriptional networks maintain sterol homeostasis across species, underscoring the importance of sterol balance for healthy life. Magner et al. (2013) now show that, in C. elegans, the nuclear receptor NHR-8 is key in regulation of cholesterol balance and production of dafachronic acid, a bile acid-like steroid that controls longevity.
摘要
广泛的转录网络在物种间维持固醇稳态，突出了固醇平衡对健康生活的重要性。Magner 等人（2013 年）现在表明，在秀丽隐杆线虫中，核受体 NHR-8 是调节胆固醇平衡和 dafachronic 酸产生的关键，dafachronic 酸是一种类似胆酸的类固醇，控制着寿命。
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