Arlia-Ciommo Anthony, Piano Amanda, Svistkova Veronika, Mohtashami Sadaf, Titorenko Vladimir I
Department of Biology, Concordia University, 7141 Sherbrooke Street, West, SP Building, Room 501-13, Montreal, QC H4B 1R6, Canada.
Int J Mol Sci. 2014 Sep 18;15(9):16522-43. doi: 10.3390/ijms150916522.
Bile acids are cholesterol-derived bioactive lipids that play essential roles in the maintenance of a heathy lifespan. These amphipathic molecules with detergent-like properties display numerous beneficial effects on various longevity- and healthspan-promoting processes in evolutionarily distant organisms. Recent studies revealed that lithocholic bile acid not only causes a considerable lifespan extension in yeast, but also exhibits a substantial cytotoxic effect in cultured cancer cells derived from different tissues and organisms. The molecular and cellular mechanisms underlying the robust anti-aging and anti-tumor effects of lithocholic acid have emerged. This review summarizes the current knowledge of these mechanisms, outlines the most important unanswered questions and suggests directions for future research.
胆汁酸是胆固醇衍生的生物活性脂质，在维持健康寿命中发挥着重要作用。这些具有去污剂样性质的两亲性分子，对进化上远缘生物中各种促进长寿和健康寿命的过程具有多种有益作用。最近的研究表明，石胆酸不仅能使酵母的寿命显著延长，还对源自不同组织和生物的培养癌细胞表现出显著的细胞毒性作用。石胆酸强大的抗衰老和抗肿瘤作用背后的分子和细胞机制已逐渐明晰。本综述总结了目前对这些机制的认识，概述了最重要的未解决问题，并提出了未来研究的方向。
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