Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Cruces University Hospital, Vizcaya, Spain; School of Medicine, Basque Country University, Spain.
Eur J Obstet Gynecol Reprod Biol. 2013 Oct;170(2):439-43. doi: 10.1016/j.ejogrb.2013.07.010. Epub 2013 Aug 8.
To assess whether, in GnRH agonist IVF cycles where there is a risk of ovarian hyperstimulation syndrome (OHSS), the addition of cabergoline to the hydroxyethyl starch (HES) infusion could decrease OHSS incidence and severity.
Prospective randomized study. The population under study consisted of women undergoing IVF cycles with GnRH agonist protocols, at risk of OHSS (more than 20 follicles observed larger than 12 mm in diameter and/or estradiol levels of 3000-5000 pg/mL). Women received a slow infusion of 500 mL of 6% HES during follicular aspiration alone or combined with 0.5mg cabergoline administration for 8 days, starting on the day of hCG administration.
The rates of OHSS (both early and late) were very similar in the HES alone group (3.19% (3/94)) and in the HES plus cabergoline group (5.68% (5/88)), as were the rates of severe cases of OHSS (1.06% and 2.27%). Pregnancy rates (PR) were also similar in the two groups (ongoing PR per transfer, 47.56% and 47.50%).
The co-administration of cabergoline in patients receiving HES due to OHSS risk did not reduce the rate or severity of OHSS in GnRH agonist IVF cycles.
评估在 GnRH 激动剂 IVF 周期中存在卵巢过度刺激综合征（OHSS）风险的情况下，向羟乙基淀粉（HES）输注中添加卡麦角林是否可以降低 OHSS 的发生率和严重程度。
前瞻性随机研究。研究人群由接受 GnRH 激动剂方案 IVF 周期的妇女组成，这些妇女有发生 OHSS 的风险（观察到超过 20 个卵泡直径大于 12 毫米和/或雌二醇水平为 3000-5000pg/mL）。妇女在卵泡抽吸时单独接受 500 毫升 6% HES 的缓慢输注，或在 hCG 给药当天开始连续 8 天接受 0.5mg 卡麦角林给药，联合 HES 输注。
HES 单独组（3.19%（3/94））和 HES 加卡麦角林组（5.68%（5/88））的 OHSS（早期和晚期）发生率非常相似，严重 OHSS 的发生率也相似（1.06%和 2.27%）。两组的妊娠率（PR）也相似（每转移的持续妊娠率，47.56%和 47.50%）。
在 GnRH 激动剂 IVF 周期中，由于 OHSS 风险而接受 HES 治疗的患者联合使用卡麦角林并未降低 OHSS 的发生率或严重程度。
