Takamizawa Y, Inaba N, Matsui H
Chiba University Faculty of Medicine, Dept. of Obstetrics & Gynecology.
Gan To Kagaku Ryoho. 1990 Sep;17(9):1843-7.
The choriocarcinoma was one of the most curable malignant neoplasms. This is chiefly because the effective chemotherapy was introduced and the sensitivity of hCG was improved. But about 10-20% cases with choriocarcinoma were drug resistant or recurrent cases. And now, the treatment of these refractory choriocarcinomas were one of the most important clinical problems. We describe a new combination chemotherapy for these refractory choriocarcinomas in this paper. This high dose 5-FU + Act-D protocol was effective for drug resistant cases with MEA protocol.
绒毛膜癌是最可治愈的恶性肿瘤之一。这主要是因为引入了有效的化疗方法，并且人绒毛膜促性腺激素（hCG）的敏感性得到了提高。但是，约10%-20%的绒毛膜癌病例存在耐药或复发情况。目前，这些难治性绒毛膜癌的治疗是最重要的临床问题之一。在本文中，我们描述了一种针对这些难治性绒毛膜癌的新联合化疗方案。这种高剂量5-氟尿嘧啶（5-FU）+放线菌素D（Act-D）方案对采用MEA方案的耐药病例有效。
