Kikuchi K, Tsuyuki A, Fujishiro Y, Utsumi T, Fujisaki M, Kurihara E, Uematsu M
Dept. of Surgery of Tokyo Denryoku Hospital.
Gan To Kagaku Ryoho. 1990 Sep;17(9):1905-8.
Malignant pleural effusion in the patients with breast cancer commonly occurs, and is a life-threatening factor. The present paper shows the usefulness of intrapleural administration of CDDP in six cases. A decrease of pleural effusions was observed in all cases. Treatment was effective in two cases of CR and four cases of PR. A median survival from initiation of intrapleural therapy is 17 months (range 2-47 months). This procedure produced distinctly fewer side effects than intravenous administration. The results of this trials suggest that CDDP should be considered as an active agent in the treatment of malignant pleural effusion in the patients with breast cancer.
乳腺癌患者常发生恶性胸腔积液，这是一个危及生命的因素。本文显示了胸膜腔内注射顺铂对6例患者的有效性。所有病例均观察到胸腔积液减少。治疗效果为2例完全缓解（CR），4例部分缓解（PR）。胸膜腔内治疗开始后的中位生存期为17个月（范围2 - 47个月）。该方法产生的副作用明显少于静脉给药。本试验结果表明，顺铂应被视为治疗乳腺癌患者恶性胸腔积液的一种有效药物。
