Albert Einstein College of Medicine, Department of Anatomy and Structural Biology, Bronx, NY 10461, United States.
Matrix Biol. 2013 Oct-Nov;32(7-8):372-80. doi: 10.1016/j.matbio.2013.07.008. Epub 2013 Aug 7.
Glioblastoma multiforme is one of the deadliest human cancers and is characterized by a high degree of microglia and macrophage infiltration. The role of these glioma infiltrating macrophages (GIMs) in disease progression has been the subject of recent investigation. While initially thought to reflect an immune response to the tumor, the balance of evidence clearly suggests GIMs can have potent tumor-tropic functions and assist in glioma cell growth and infiltration into normal brain. In this review, we focus on the evidence for GIMs aiding mediating glioblastoma motility and invasion. We survey the literature for molecular pathways that are involved in paracrine interaction between glioma cells and GIMs and assess which of these might serve as attractive targets for therapeutic intervention.
多形性胶质母细胞瘤是人类最致命的癌症之一，其特征是存在高度的小胶质细胞和巨噬细胞浸润。这些浸润性神经胶质瘤巨噬细胞（GIM）在疾病进展中的作用是最近研究的主题。尽管最初认为这反映了对肿瘤的免疫反应，但越来越多的证据清楚地表明，GIM 可以具有强大的肿瘤趋向性功能，并有助于神经胶质瘤细胞的生长和浸润正常大脑。在这篇综述中，我们重点关注 GIM 辅助介导胶质母细胞瘤运动和侵袭的证据。我们查阅了文献中涉及神经胶质瘤细胞和 GIM 之间旁分泌相互作用的分子途径，并评估了其中哪些可能成为有吸引力的治疗干预靶点。
