急性髓系白血病中一种与 EGF 和 ELOVL6 失调相关的新型 t(4;16)(q25;q23.1)。
A novel t(4;16)(q25;q23.1) associated with EGF and ELOVL6 deregulation in acute myeloid leukemia.
机构信息
Department of Emergency and Organ Transplantation (D.E.T.O.), Hematology Section, University of Bari, 70124 Bari, Italy.
出版信息
Gene. 2013 Oct 15;529(1):144-7. doi: 10.1016/j.gene.2013.07.105. Epub 2013 Aug 9.
About 50% of acute myeloid leukemia (AML) patients show the occurrence of non-random chromosome rearrangements. Most of the recurrent karyotypic rearrangements in AML have been defined as distinct disease entities in the 2008 World Health Organization (WHO) classification. In this paper we report an AML case showing a novel t(4;16)(q25;q23.1) rearrangement causing the activation of epidermal growth factor (EGF) and elongation of long-chain fatty acids family member 6 (ELOVL6) genes, rather than the generation of a novel fusion gene.
约 50%的急性髓系白血病（AML）患者表现出非随机染色体重排。在 2008 年世界卫生组织（WHO）分类中，AML 中大多数反复出现的核型重排已被定义为不同的疾病实体。在本文中，我们报告了一个 AML 病例，该病例显示了一种新型的 t(4;16)(q25;q23.1)重排，导致表皮生长因子（EGF）的激活和长链脂肪酸家族成员 6（ELOVL6）基因的延长，而不是产生新的融合基因。
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