GM-CSF 作为炎症性疾病的治疗靶点。
GM-CSF as a therapeutic target in inflammatory diseases.
机构信息
Inflammation Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia; Department of Rheumatology and Advanced Therapeutics, University Medical Centre Nijmegen, Nijmegen, The Netherlands; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.
出版信息
Mol Immunol. 2013 Dec;56(4):675-82. doi: 10.1016/j.molimm.2013.05.002. Epub 2013 Aug 8.
GM-CSF is a well-known haemopoietic growth factor that is used in the clinic to correct neutropaenia, usually as a result of chemotherapy. GM-CSF also has many pro-inflammatory functions and recent data implicates GM-CSF as a key factor in Th17 driven autoimmune inflammatory conditions. In this review we summarize the findings that have led to the development of GM-CSF antagonists for the treatment of autoimmune diseases like rheumatoid arthritis (RA) and discuss some results of recent clinical trials of these agents.
GM-CSF 是一种众所周知的造血生长因子，临床上常用于纠正因化疗引起的中性粒细胞减少症。GM-CSF 还具有许多促炎功能，最近的数据表明 GM-CSF 是 Th17 驱动的自身免疫性炎症疾病的关键因素。在这篇综述中，我们总结了导致 GM-CSF 拮抗剂开发用于治疗类风湿关节炎（RA）等自身免疫性疾病的发现，并讨论了这些药物最近临床试验的一些结果。
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