无症状腔隙性梗死与脑萎缩和认知障碍的关系。
Association of silent lacunar infarct with brain atrophy and cognitive impairment.
机构信息
Department of Bioengineering, National University of Singapore, , Singapore, Singapore.
出版信息
J Neurol Neurosurg Psychiatry. 2013 Nov;84(11):1219-25. doi: 10.1136/jnnp-2013-305310. Epub 2013 Aug 9.
OBJECTIVE
Silent lacunar infarct (SLI) is associated with cognitive decline and linked to an increased risk of stroke and dementia. We examined the association of SLI with MRI measures of cortical thickness, subcortical and lateral ventricular shapes and cognition in 285 ethnic Chinese elderly.
METHODS
SLI, cortical thickness, shapes of subcortical and ventricular structures were quantified using MRI. The cognitive performance was assessed using comprehensive neuropsychological tests. Linear regression was used to examine associations among SLI, brain measures and cognition.
RESULTS
SLI was associated with atrophy in multiple subcortical structures, ventricular enlargement and widespread cortical thinning. Both SLI and atrophy were independently related to poorer performance in attention, memory and language domains. Only SLI was associated with visuomotor speed and executive function, while atrophy mediated the association between SLI and visuoconstruction.
CONCLUSIONS
Our findings support a vascular contribution to neurodegeneration and cognitive impairment.
目的
无症状腔隙性梗死（SLI）与认知能力下降有关，并且与中风和痴呆的风险增加有关。我们研究了 SLI 与皮质厚度、皮质下和侧脑室形状以及 285 名华裔老年人认知能力的 MRI 测量值之间的关系。
方法
使用 MRI 定量评估 SLI、皮质厚度、皮质下和脑室结构的形状。使用综合神经心理学测试评估认知表现。线性回归用于检查 SLI、大脑测量值和认知之间的关系。
结果
SLI 与多个皮质下结构的萎缩、脑室扩大和广泛的皮质变薄有关。SLI 和萎缩都与注意力、记忆和语言领域的表现较差独立相关。只有 SLI 与视运动速度和执行功能有关，而萎缩则介导了 SLI 与视空间构建之间的关联。
结论
我们的研究结果支持血管性神经退行性变和认知障碍的发生。
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