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Early engraftment and full-donor chimerism after single-cord blood plus third-party donor dual transplantation in patients with high-risk acute leukemia.

作者信息

Sánchez-Ortega I, Arnan M, Patiño B, Herrero M J, Querol S, Duarte R F

机构信息

1] Department of Haematology, Catalan Institute of Oncology (ICO)-Hospital Duran i Reynals, Barcelona, Spain [2] Group of Hematological Malignancies, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.

Laboratori d'Immunobiologia per a la Reçerca i Aplicacions Diagnòstiques (LIRAD), Banc de Sang i Teixits, Barcelona, Spain.

出版信息

Bone Marrow Transplant. 2014 Jan;49(1):145-7. doi: 10.1038/bmt.2013.113. Epub 2013 Aug 12.

DOI:10.1038/bmt.2013.113
PMID:23933757
Abstract
摘要

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1
Early engraftment and full-donor chimerism after single-cord blood plus third-party donor dual transplantation in patients with high-risk acute leukemia.高危急性白血病患者单份脐血加第三方供者双重移植后的早期植入和完全供者嵌合状态
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2
Single-unit dominance after double-unit umbilical cord blood transplantation coincides with a specific CD8+ T-cell response against the nonengrafted unit.双份脐血单个核细胞移植后出现单个核细胞优势与针对未植入供者的特异性 CD8+ T 细胞反应有关。
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3
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引用本文的文献

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Sequential Transplantation of Haploidentical Stem Cell and Unrelated Cord Blood With Using ATG/PTCY Increases Survival of Relapsed/Refractory Hematologic Malignancies.序贯移植单倍体相合造血干细胞和无关脐带血联合使用 ATG/PTCY 可提高复发/难治性血液系统恶性肿瘤的生存率。
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Bone Marrow Transplant. 2015 Aug;50(8):1037-56. doi: 10.1038/bmt.2015.6. Epub 2015 Mar 23.

本文引用的文献

1
Single cord blood combined with HLA-mismatched third party donor cells: comparable results to matched unrelated donor transplantation in high-risk patients with hematologic disorders.单份脐带血联合 HLA 不合的第三方供者细胞：与高危血液系统疾病患者的相合无关供者移植相比具有相当的结果。
Biol Blood Marrow Transplant. 2013 Jan;19(1):143-9. doi: 10.1016/j.bbmt.2012.08.019. Epub 2012 Sep 6.
2
Reduced-intensity conditioning with combined haploidentical and cord blood transplantation results in rapid engraftment, low GVHD, and durable remissions.采用亲缘单倍体相合联合脐带血移植的减低强度预处理方案可实现快速植入、低移植物抗宿主病发生率和持久缓解。
Blood. 2011 Dec 8;118(24):6438-45. doi: 10.1182/blood-2011-08-372508. Epub 2011 Oct 5.
3
Efficacy and safety of ciprofloxacin for prophylaxis of polyomavirus BK virus-associated hemorrhagic cystitis in allogeneic hematopoietic stem cell transplantation recipients.
环丙沙星预防异基因造血干细胞移植受者 BK 多瘤病毒相关性出血性膀胱炎的疗效和安全性。
Biol Blood Marrow Transplant. 2011 Aug;17(8):1176-81. doi: 10.1016/j.bbmt.2010.12.700. Epub 2010 Dec 23.
4
Defining the intensity of conditioning regimens: working definitions.定义预处理强度：工作定义。
Biol Blood Marrow Transplant. 2009 Dec;15(12):1628-33. doi: 10.1016/j.bbmt.2009.07.004. Epub 2009 Sep 1.
5
Improving outcomes of cord blood transplantation: HLA matching, cell dose and other graft- and transplantation-related factors.提高脐带血移植的疗效：HLA 配型、细胞剂量和其他移植物及移植相关因素。
Br J Haematol. 2009 Oct;147(2):262-74. doi: 10.1111/j.1365-2141.2009.07883.x.
6
Improving the outcome of cord blood transplantation: use of mobilized HSC and other cells from third party donors.提高脐带血移植的疗效：利用动员的 HSC 和其他第三方供者来源的细胞。
Br J Haematol. 2009 Oct;147(2):161-76. doi: 10.1111/j.1365-2141.2009.07766.x.
7
Donor selection for unrelated cord blood transplants.非亲缘脐血移植的供者选择
Curr Opin Immunol. 2006 Oct;18(5):565-70. doi: 10.1016/j.coi.2006.07.014. Epub 2006 Aug 8.
8
Cord-blood transplantation in patients with leukemia--a real alternative for adults.
N Engl J Med. 2004 Nov 25;351(22):2328-30. doi: 10.1056/NEJMe048275.