Rao Jianhua, Feng Min, Qian Xiaofeng, Li Guoqiang, Wang Xuehao, Zhang Feng, Lu Ling
Hepatogastroenterology. 2013 Sep;60(126):1317-9. doi: 10.5754/hge13185.
For the first time ever, sorafenib-induced hepatic failure has been cured by liver transplantation. A 54-year-old man, he underwent surgery for papillary carcinoma of thyroid gland two years ago. After two years follow up, a left neck lymph node metastasis was found and he was treated with sorafenib (800 mg/day). However, two days later, hepatic failure associated with sorafenib developed and he was treated with liver transplantation. The donor was a victim of road accident. Even though hepatic failure associated with sorafenib treatment is rare, the possible development of hepatic failure in patients undergoing sorafenib treatment must be kept in mind.
索拉非尼诱导的肝衰竭首次通过肝移植治愈。一名54岁男性，两年前接受了甲状腺乳头状癌手术。经过两年随访，发现左颈部淋巴结转移，遂接受索拉非尼治疗（800毫克/天）。然而，两天后，出现了与索拉非尼相关的肝衰竭，随后接受了肝移植。供体是一名交通事故受害者。尽管与索拉非尼治疗相关的肝衰竭很少见，但在接受索拉非尼治疗的患者中必须牢记肝衰竭可能发生。
