糖尿病肾病的代谢组学分析。
Metabolic phenotyping of diabetic nephropathy.
机构信息
1] Department of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, California, USA [2] Computational Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland [3] Folkhälsan Institute of Genetics, Biomedicum Helsinki, Helsinki, Finland.
出版信息
Clin Pharmacol Ther. 2013 Nov;94(5):566-9. doi: 10.1038/clpt.2013.158. Epub 2013 Aug 9.
Diabetic nephropathy is the most serious complication of type 1 diabetes. There is no treatment to protect the kidneys from poorly controlled diabetes, and therefore prevention of the initial metabolic insults is currently the only effective approach to reducing the high mortality related to diabetic nephropathy. Metabolic phenotyping brings us one step closer to understanding the unique set of regulatory perturbations that predispose to kidney injury and paves the way for multiparametric risk assessment.
糖尿病肾病是 1 型糖尿病最严重的并发症。目前还没有治疗方法可以保护肾脏免受控制不佳的糖尿病的影响，因此，预防最初的代谢损伤是目前降低与糖尿病肾病相关高死亡率的唯一有效方法。代谢表型分析使我们更深入地了解导致肾脏损伤的独特的调节失调，并为多参数风险评估铺平了道路。
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