Counter-regulatory effects of phosphatidic acid on protein kinase C activity in the presence of calcium and diolein.
作者信息
Epand R M, Stafford A R
机构信息
Department of Biochemistry, McMaster University, Health Sciences Centre, Hamilton, Ontario, Canada.
出版信息
Biochem Biophys Res Commun. 1990 Aug 31;171(1):487-90. doi: 10.1016/0006-291x(90)91419-s.
PMID:2393403
Abstract
Phosphatidic acid can replace phosphatidylserine in the activation of protein kinase C. However, in the presence of diolein, the addition of Ca2+ results in the inhibition of the enzyme. This phenomenon could lead to a negative feedback regulation of protein kinase C activity as a result of stimulation of the cycling of phosphatidylinositol.
摘要
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