Department of Obstetrics and Gynecology, Faculty of Health Sciences, Soroka University Medical Center, Ben-Gurion University of the Negev, POB 151, Beersheba, 84101, Israel.
Arch Gynecol Obstet. 2013 Oct;288(4):725-30. doi: 10.1007/s00404-013-2989-3. Epub 2013 Aug 10.
The association between inflammatory bowel disease (IBD) and preterm delivery is controversial. Study size, quality, and design have been inconsistent, making it difficult to assess the relationship between IBD and preterm delivery.
Utilizing a systematic search of Pubmed for all relevant literature, this review seeks to clarify the correlation between IBD and preterm delivery and to assess the impact of disease activity and medication usage on this outcome.
The available evidence is inadequate to make any robust claims about the association between IBD and preterm delivery. IBD in pregnant women may represent a risk for preterm delivery, and it is probable that IBD activity augments this risk. Many of the medications used to treat IBD also have a correlation with preterm delivery.
While an association between IBD and preterm delivery may exist, further well-designed prospective studies are necessary to determine how the course and management of disease may impact this outcome.
炎症性肠病（IBD）与早产之间的关联存在争议。研究规模、质量和设计一直不一致，因此难以评估 IBD 与早产之间的关系。
通过对 Pubmed 进行系统检索，查找所有相关文献，本综述旨在阐明 IBD 与早产之间的相关性，并评估疾病活动度和药物使用对这一结果的影响。
目前的证据不足以对 IBD 与早产之间的关联做出任何强有力的结论。孕妇的 IBD 可能代表早产的风险，而且 IBD 活动可能会增加这种风险。许多用于治疗 IBD 的药物也与早产有关。
虽然 IBD 与早产之间可能存在关联，但需要进一步进行精心设计的前瞻性研究，以确定疾病的病程和管理如何影响这一结果。
