通过酰胺基炔的分子内铜介导的碳镁化反应制备功能化吲哚和氮杂吲哚。
Preparation of functionalized indoles and azaindoles by the intramolecular copper-mediated carbomagnesiation of ynamides.
机构信息
Ludwig Maximilians-Universität München, Department Chemie, Butenandtstrasse 5-13, Haus F, 81377 München (Germany).
出版信息
Angew Chem Int Ed Engl. 2013 Sep 16;52(38):10084-8. doi: 10.1002/anie.201304380. Epub 2013 Aug 9.
PMID:23934952
Abstract
Variations on a theme: A mild and general intramolecular copper-mediated carbomagnesiation procedure for the synthesis of functionalized indoles as well as 4-, 5-, 6-, and 7-azaindoles starts from readily available ynamides. Subsequent reactions with various electrophiles provides polyfunctional N-heterocycles in good yields.
摘要
变奏主题
一种温和而通用的分子内铜介导碳镁化方法，用于合成功能化吲哚以及 4-、5-、6-和 7-氮杂吲哚，该方法起始原料为易得的炔酰胺。随后与各种亲电试剂的反应以良好的收率提供了多官能团的 N-杂环化合物。
Zotero 插件