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多发性硬化症患者大剂量使用类固醇后发生脑静脉血栓形成:一例报告

Cerebral venous thrombosis after high dose steroid in multiple sclerosis: a case report.

作者信息

Gazioglu S, Solmaz D, Boz C

机构信息

Department of Neurology, Karadeniz Technical University Medical Faculty, Trabzon, Turkey.

出版信息

Hippokratia. 2013 Jan;17(1):88-90.

PMID:23935354
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3738289/
Abstract

Cerebral venous thrombosis (CVT) is a clinical condition which is caused by the partial or complete occlusion of the dural sinuses and cerebral veins. Cases of associated CVT and multiple sclerosis (MS) have been reported and CVT development has been attributed to the previous lumbar puncture (LP) in majority of these cases. We report a case of 32-year-old woman with no previous history of recent LP, who developed CVT after high dose intravenous methylprednisolone and discuss the possible role of high dose steroids in development of CVT in MS patients.

摘要

脑静脉血栓形成(CVT)是一种由硬脑膜窦和脑静脉部分或完全闭塞引起的临床病症。已有CVT与多发性硬化症(MS)相关的病例报道,在大多数此类病例中,CVT的发生归因于先前的腰椎穿刺(LP)。我们报告一例32岁女性,既往无近期LP史,在接受大剂量静脉注射甲基强的松龙后发生CVT,并讨论大剂量类固醇在MS患者CVT发生中的可能作用。

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本文引用的文献

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Venous thrombosis in multiple sclerosis patients after high-dose intravenous methylprednisolone: the preventive effect of enoxaparin.大剂量静脉注射甲泼尼龙后多发性硬化症患者的静脉血栓形成:依诺肝素的预防作用
Thrombosis. 2011;2011:785459. doi: 10.1155/2011/785459. Epub 2011 Dec 25.
2
Changes in coagulation indexes and occurrence of venous thromboembolism in patients with Cushing's syndrome: results from a prospective study before and after surgery.库欣综合征患者凝血指标的变化及静脉血栓栓塞的发生:手术前后前瞻性研究的结果。
Eur J Endocrinol. 2010 Nov;163(5):783-91. doi: 10.1530/EJE-10-0583. Epub 2010 Aug 9.
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Cerebral venous sinus thrombosis risk factors.脑静脉窦血栓形成的危险因素。
Int J Stroke. 2009 Apr;4(2):111-23. doi: 10.1111/j.1747-4949.2009.00260.x.
4
Cerebral venous thrombosis and demyelinating diseases: report of a case in a clinically isolated syndrome suggestive of multiple sclerosis onset and review of the literature.脑静脉血栓形成与脱髓鞘疾病:1例提示多发性硬化症起病的临床孤立综合征病例报告及文献综述
Mult Scler. 2005 Apr;11(2):242-4. doi: 10.1191/1352458505ms1125cr.
5
Femoral head blood flow reduction and hypercoagulability under 24 h megadose steroid treatment in pigs.猪在24小时大剂量类固醇治疗下的股骨头血流减少和高凝状态。
J Orthop Res. 2004 May;22(3):501-8. doi: 10.1016/j.orthres.2003.10.002.
6
High-dose corticosteroid treatment is associated with an increased risk of developing cerebral venous thrombosis.大剂量皮质类固醇治疗与发生脑静脉血栓形成的风险增加有关。
Eur Neurol. 2003;49(4):247-8. doi: 10.1159/000070197.
7
Cerebral venous thrombosis in four patients with multiple sclerosis.4例多发性硬化患者的脑静脉血栓形成
Eur J Neurol. 2003 Jan;10(1):63-6. doi: 10.1046/j.1468-1331.2003.00513.x.
8
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