Department of Tumor Chemotherapy, Affiliated Hospital of Nantong University, Medical College, Nantong University, Nantong, Jiangsu, China.
PLoS One. 2013 Jul 23;8(7):e69148. doi: 10.1371/journal.pone.0069148. Print 2013.
Nemo-like kinase (NLK), a mediator of the Wnt signaling pathway, binds directly to c-Myb, leading to its phosphorylation, ubiquitination and proteasome-dependent degradation. NLK was significantly downregulated in the breast cancer tissues compared to corresponding normal tissues. NLK expression was negatively correlated with c-Myb expression. NLK suppressed proliferation, induced apoptosis and mediated c-Myb degradation in MCF-7 cells via a mechanism that seems to involve c-myc and Bcl2. These findings might provide a novel target for therapeutic intervention in patients with breast cancer.
Nemo 样激酶（NLK）是 Wnt 信号通路的介质，可直接与 c-Myb 结合，导致其磷酸化、泛素化和蛋白酶体依赖性降解。与相应的正常组织相比，NLK 在乳腺癌组织中显著下调。NLK 表达与 c-Myb 表达呈负相关。NLK 通过一种似乎涉及 c-myc 和 Bcl2 的机制抑制 MCF-7 细胞的增殖、诱导凋亡并介导 c-Myb 降解。这些发现可能为乳腺癌患者的治疗干预提供新的靶点。
