Hormone-induced intracellular calcium oscillations and mitochondrial energy supply in single hepatocytes.

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作者信息

Reber B F, Somogyi R, Stucki J W

机构信息

Pharmakologisches Institut, Universität Bern, Switzerland.

出版信息

Biochim Biophys Acta. 1990 Jul 25;1018(2-3):190-3. doi: 10.1016/0005-2728(90)90246-z.

DOI:10.1016/0005-2728(90)90246-z

PMID:2393657

Abstract

摘要

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Hormone-induced intracellular calcium oscillations and mitochondrial energy supply in single hepatocytes.

Biochim Biophys Acta. 1990 Jul 25;1018(2-3):190-3. doi: 10.1016/0005-2728(90)90246-z.

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alpha-Adrenergic mobilization of hepatic mitochondrial calcium.肝线粒体钙的α-肾上腺素能动员

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Stable changes to calcium fluxes in mitochondria isolated from rat livers perfused with alpha-adrenergic agonists and with glucagon.在用α-肾上腺素能激动剂和胰高血糖素灌注的大鼠肝脏中分离出的线粒体中，钙通量发生稳定变化。

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Measurement of the intramitochondrial volume in hepatocytes without cell disruption and its elevation by hormones and valinomycin.在不破坏细胞的情况下测量肝细胞线粒体内的体积及其受激素和缬氨霉素的影响而增加的情况。

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Different modulatory effects of elevated cyclic AMP on cytosolic Ca2+ spikes induced by phenylephrine or vasopressin in single rat hepatocytes.环磷酸腺苷升高对苯肾上腺素或血管加压素诱导的单个大鼠肝细胞胞质钙离子峰的不同调节作用。

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The effects of glucagon, phenylephrine and insulin on the phosphorylation of cytoplasmic, mitochondrial and membrane-bound proteins of intact liver cells from starved rats.胰高血糖素、去氧肾上腺素和胰岛素对饥饿大鼠完整肝细胞的细胞质、线粒体及膜结合蛋白磷酸化的影响。

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Calcium: its modulation in liver by cross-talk between the actions of glucagon and calcium-mobilizing agonists.钙：胰高血糖素与钙动员激动剂作用之间的相互作用对其在肝脏中的调节

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The relationship between the cytosolic free calcium ion concentration and the control of pyruvate dehydrogenase.

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引用本文的文献

Glucagon, cyclic AMP, and hepatic glucose mobilization: A half-century of uncertainty.胰高血糖素、环腺苷酸和肝糖动员：半个世纪的不确定性。

Physiol Rep. 2022 May;10(9):e15263. doi: 10.14814/phy2.15263.

Time-resolved spectroscopy of mitochondria, cells and tissues under normal and pathological conditions.正常和病理条件下线粒体、细胞及组织的时间分辨光谱学

Mol Cell Biochem. 1998 Jul;184(1-2):445-55.

Contribution of the mitochondrial compartment to the optical properties of the rat liver: a theoretical and practical approach.线粒体区室对大鼠肝脏光学特性的贡献：一种理论与实践方法

Biophys J. 1994 Dec;67(6):2501-10. doi: 10.1016/S0006-3495(94)80740-4.

Dehydrogenase activation by Ca2+ in cells and tissues.细胞和组织中钙离子对脱氢酶的激活作用。

J Bioenerg Biomembr. 1991 Dec;23(6):823-54. doi: 10.1007/BF00786004.

Modulation of cytosolic-[Ca2+] oscillations in hepatocytes results from cross-talk among second messengers. The synergism between the alpha 1-adrenergic response, glucagon and cyclic AMP, and their antagonism by insulin and diacylglycerol manifest themselves in the control of the cytosolic-[Ca2+] oscillations.肝细胞中胞质[Ca2+]振荡的调节源于第二信使之间的相互作用。α1-肾上腺素能反应、胰高血糖素和环磷酸腺苷之间的协同作用，以及它们与胰岛素和二酰基甘油之间的拮抗作用，在胞质[Ca2+]振荡的控制中得以体现。

Biochem J. 1992 Sep 15;286 ( Pt 3)(Pt 3):869-77. doi: 10.1042/bj2860869.

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