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同一患者体内两种不同生物材料的软骨下骨再生效果

Subchondral bone regenerative effect of two different biomaterials in the same patient.

作者信息

Cavallo Marco, Buda Roberto, Vannini Francesca, Castagnini Francesco, Ruffilli Alberto, Giannini Sandro

机构信息

I Clinic, Rizzoli Orthopaedic Institute, Bologna University, Via Giulio Cesare Pupilli 1, 40136 Bologna, Italy.

出版信息

Case Rep Orthop. 2013;2013:850502. doi: 10.1155/2013/850502. Epub 2013 Jul 7.

DOI:10.1155/2013/850502
PMID:23936705
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3722982/
Abstract

This case report aims at highlighting the different effects on subchondral bone regeneration of two different biomaterials in the same patient, in addition to bone marrow derived cell transplantation (BMDCT) in ankle. A 15-year-old boy underwent a first BMDCT on a hyaluronate membrane to treat a deep osteochondral lesion (8 mm). The procedure failed: subchondral bone was still present at MRI. Two years after the first operation, the same procedure was performed on a collagen membrane with DBM filling the defect. After one year, AOFAS score was 100 points, and MRI showed a complete filling of the defect. The T2 mapping MRI after one year showed chondral tissue with values in the range of hyaline cartilage. In this case, DBM and the collagen membrane were demonstrated to be good biomaterials to restore subchondral bone: this is a critical step towards the regeneration of a healthy hyaline cartilage.

摘要

本病例报告旨在强调在同一名患者中，两种不同生物材料对踝关节软骨下骨再生的不同影响，此外还涉及骨髓源性细胞移植（BMDCT）。一名15岁男孩首次在透明质酸盐膜上进行骨髓源性细胞移植，以治疗深部骨软骨损伤（8毫米）。该手术失败：MRI显示仍存在软骨下骨。首次手术后两年，在胶原膜上进行相同手术，并用脱钙骨基质填充缺损。一年后，美国足踝外科协会（AOFAS）评分为100分，MRI显示缺损完全填充。一年后的T2映射MRI显示软骨组织的值在透明软骨范围内。在这种情况下，脱钙骨基质和胶原膜被证明是恢复软骨下骨的良好生物材料：这是朝着健康透明软骨再生迈出的关键一步。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39bf/3722982/cf0a13bdb92f/CRIM.ORTHOPEDICS2013-850502.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39bf/3722982/1041df694fee/CRIM.ORTHOPEDICS2013-850502.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39bf/3722982/f2d6eedd0139/CRIM.ORTHOPEDICS2013-850502.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39bf/3722982/a99c6dd223fd/CRIM.ORTHOPEDICS2013-850502.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39bf/3722982/cf0a13bdb92f/CRIM.ORTHOPEDICS2013-850502.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39bf/3722982/1041df694fee/CRIM.ORTHOPEDICS2013-850502.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39bf/3722982/f2d6eedd0139/CRIM.ORTHOPEDICS2013-850502.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39bf/3722982/a99c6dd223fd/CRIM.ORTHOPEDICS2013-850502.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39bf/3722982/cf0a13bdb92f/CRIM.ORTHOPEDICS2013-850502.004.jpg

相似文献

[1]
Subchondral bone regenerative effect of two different biomaterials in the same patient.

Case Rep Orthop. 2013

[2]
Regenerative treatment in osteochondral lesions of the talus: autologous chondrocyte implantation versus one-step bone marrow derived cells transplantation.

Int Orthop. 2015-5

[3]
Validity of T2 mapping in characterization of the regeneration tissue by bone marrow derived cell transplantation in osteochondral lesions of the ankle.

Eur J Radiol. 2010-8-30

[4]
Improved cartilage regeneration by implantation of acellular biomaterials after bone marrow stimulation: a systematic review and meta-analysis of animal studies.

PeerJ. 2016-9-8

[5]
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[6]
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J Vis Exp. 2013-5-21

[7]
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Am J Sports Med. 2013-10-10

[8]
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Cartilage. 2015-7

[9]
[Treatment of deep cartilage defects of the knee with autologous chondrocyte transplantation on a hyaluronic Acid ester scaffolds (Hyalograft C)].

Acta Chir Orthop Traumatol Cech. 2006-8

[10]
Clinical and Radiological Regeneration of Large and Deep Osteochondral Defects of the Knee by Bone Augmentation Combined With Matrix-Guided Autologous Chondrocyte Transplantation.

Am J Sports Med. 2017-11

引用本文的文献

[1]
Treatment of osteochondral lesions of the talus in athletes: what is the evidence?

Joints. 2016-8-18

[2]
Pulsed electromagnetic fields combined with a collagenous scaffold and bone marrow concentrate enhance osteochondral regeneration: an in vivo study.

BMC Musculoskelet Disord. 2015-9-2

本文引用的文献

[1]
Guided bone regeneration in long-bone defects with a structural hydroxyapatite graft and collagen membrane.

Tissue Eng Part A. 2012-9-14

[2]
Reconstruction of a large osteochondral lesion of the distal tibia with an iliac crest graft and autologous matrix-induced chondrogenesis (AMIC): a case report.

J Foot Ankle Surg. 2012

[3]
Cartilage tissue engineering of nasal septal chondrocyte-macroaggregates in human demineralized bone matrix.

Cell Tissue Bank. 2013-6

[4]
Mixture of hyaluronic acid, chondroitin 6 sulphate and dermatan sulphate used to completely regenerate bone in rat critical size defect model.

J Craniomaxillofac Surg. 2012-3-30

[5]
Autologous bone marrow grafting combined with demineralized bone matrix improves consolidation of docking site after distraction osteogenesis.

J Bone Joint Surg Am. 2011-4-6

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Injury. 2010-10-8

[7]
Validity of T2 mapping in characterization of the regeneration tissue by bone marrow derived cell transplantation in osteochondral lesions of the ankle.

Eur J Radiol. 2010-8-30

[8]
Minimally invasive bone grafting of cysts of the femoral head and acetabulum in femoroacetabular impingement: arthroscopic technique and case presentation.

Arthroscopy. 2010-2

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Clin Podiatr Med Surg. 2009-4

[10]
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Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2006-12

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