Chiamchanya Nichapa
Blood Bank Unit, Allied Health Sciences Department, Thammasat University Hospital, Pathumthani, Thailand.
J Med Assoc Thai. 2013 Feb;96(2):165-71.
Iron deficiency anemia has occurred more frequently in female than male regular blood donors. Iron supplement is necessary for maintaining the hemoglobin level. A combination with ascorbic acid increases the absorption of iron.
Compare the effect of ferrous fumarate 200 mg/day and the combination of ferrous fumarate 200 mg/day with ascorbic acid 100 mg/day and 500 mg/day on hemoglobin level and red blood cell indices in female regular blood donors.
Female regular blood donor volunteers were randomly divided into three equal groups to supplement with each regimen for one month. Hemoglobin (Hb), MCV, MCH, and MCHC before and after blood donation at 0.5, 1, 2, and 3 months, were compared.
Ninety-six volunteers were included and equally divided into three groups of 32 volunteers each. There were no significant differences between age, BMI, ABO blood group, Rh, Hb, MC, MCH, and MCHC before blood donation between each group (p > 0.05). The duration of recovery times of Hb to before blood donation levels in group I, II, and III being 2, 3, and 1 month, respectively were statistically significant difference (p < 0.001). The duration of recovery times of MCV, MCH, and MCHC to before blood donation levels in both group II and III were similar (0.5 months in every value), which was more rapid than in group I (> 3, 3, and 1 month, respectively) with statistically significant difference (p < 0.001). All three groups tolerated well. No participant withdrew from the present study because of side effects.
The present study shows that a combination of ferrous fumarate 200 mg and ascorbic acid 500 mg per day accelerates timing of hemoglobin and red blood cell indices in recovery to the level of before blood donation in female regular blood donors.
缺铁性贫血在女性定期献血者中比男性更常见。补充铁剂对于维持血红蛋白水平是必要的。与抗坏血酸联合使用可增加铁的吸收。
比较每日200毫克富马酸亚铁以及每日200毫克富马酸亚铁分别与100毫克和500毫克抗坏血酸联合使用对女性定期献血者血红蛋白水平和红细胞指数的影响。
将女性定期献血志愿者随机分为三组，每组人数相等，每组采用一种方案补充铁剂，为期一个月。比较献血后0.5、1、2和3个月时血红蛋白（Hb）、平均红细胞体积（MCV）、平均红细胞血红蛋白含量（MCH）和平均红细胞血红蛋白浓度（MCHC）。
纳入96名志愿者，平均分为三组，每组32名。各组献血前年龄、体重指数（BMI）、ABO血型、Rh血型、Hb、MCV、MCH和MCHC之间无显著差异（p>0.05）。第一组、第二组和第三组血红蛋白恢复到献血前水平的时间分别为2个月、3个月和1个月，差异有统计学意义（p<0.001）。第二组和第三组MCV、MCH和MCHC恢复到献血前水平的时间相似（每个指标均为0.5个月），比第一组更快（分别>3个月、3个月和1个月），差异有统计学意义（p<0.001）。所有三组耐受性良好。没有参与者因副作用退出本研究。
本研究表明，每日200毫克富马酸亚铁与500毫克抗坏血酸联合使用可加速女性定期献血者血红蛋白和红细胞指数恢复到献血前水平的时间。
