Peninsula College of Medicine and Dentistry, Royal Devon and Exeter Hospital, Exeter, UK and.
Clin Exp Dermatol. 2013 Dec;38(8):857-61. doi: 10.1111/ced.12149. Epub 2013 Aug 13.
Multiple periungual Bowen disease [BD; also known as squamous cell carcinoma (SCC) in situ] is rare. The pathogenesis of the disease is linked to human papilloma virus, and in some instances to chronic immunosuppression. The usual management of periungual BD is by local excision, Mohs micrographic surgery or distal phalanx amputation. Our patient was offered radiotherapy in the hope of maximizing residual function and minimizing morbidity from treatment. A good response was seen at 2 months post-radiotherapy, but this was followed by relapses at 4 and 6 months post-radiotherapy. Persistent anonychia resulted in improved access to the involved skin, making topical therapy possible. Radiotherapy can be a valuable management approach for periungual SCC/BD in locations where amputation could result in substantial disability.
多发性甲周 Bowen 病[BD；也称为原位鳞状细胞癌（SCC）]较为罕见。该病的发病机制与人类乳头瘤病毒有关，在某些情况下与慢性免疫抑制有关。甲周 BD 的常规治疗方法是局部切除、Mohs 显微外科手术或末节指骨切除术。我们的患者接受了放疗，以期最大限度地保留残余功能并减少治疗的发病率。放疗后 2 个月观察到良好的反应，但随后在放疗后 4 个月和 6 个月复发。持续的无甲导致受累皮肤更容易进入，从而可以进行局部治疗。对于可能导致严重残疾的位置的甲周 SCC/BD，放疗是一种有价值的治疗方法。
