Department of Nephrology and Clinical Transplantation .
Ren Fail. 2013 Oct;35(9):1269-72. doi: 10.3109/0886022X.2013.823997. Epub 2013 Aug 12.
Kidney paired donation (KPD) is feasible for any center that performs living related donor renal transplantation (LRDRTx). Lack of awareness, counseling and participation are important hurdles in KPD patients with incompatible donors.
This is an institutional review board approved study of 10 ESRD patients who consented to participate in the KPD transplantation at our center. All the surgeries were carried out on the same day at the same center on the occasion of World Kidney Day (WKD) (14 March 2013). All recipients had anatomic, functional and immunological similar donors.
KPD were performed to avoid blood group incompatibility (n = 8) or to avoid a positive crossmatch (n = 2). None of the patients experienced delayed graft function and surgical complications. At 3 month follow-up, median serum creatinine was 1 (range 0.6 to 1.25) mg/dL and two patients developed allograft biopsy-proven acute rejection and responded to antirejection therapy. Due to impact of our awareness activity, 20 more KPD patients are medically fit for transplantation and waiting for permission from the authorization committee before transplantation.
This is a report of 10 simultaneous KPD transplantations in a single day in a single centre on WKD raising awareness of KPD. KPD is viable, legal and rapidly growing modality for facilitating LRDRTx for patients who are incompatible with their healthy, willing LRD.
对于任何开展活体亲属供肾移植（LRDRTx）的中心来说，进行肾对肾配对捐赠（KPD）都是可行的。缺乏认识、咨询和参与是 KPD 患者与不匹配供体之间的重要障碍。
这是一项机构审查委员会批准的研究，纳入了 10 名同意在我们中心进行 KPD 移植的 ESRD 患者。所有手术均于世界肾脏日（WKD）（2013 年 3 月 14 日）当天在同一中心进行。所有受者均具有解剖学、功能和免疫学相似的供者。
KPD 的实施是为了避免血型不合（n=8）或避免交叉配型阳性（n=2）。所有患者均未出现延迟移植物功能和手术并发症。在 3 个月的随访中，中位数血清肌酐为 1（范围 0.6 至 1.25）mg/dL，2 名患者发生经移植肾活检证实的急性排斥反应，并对抗排斥治疗有反应。由于我们的意识活动的影响，有 20 名符合条件的 KPD 患者正在等待授权委员会的移植许可。
这是在 WKD 当天在单一中心进行的 10 例同时 KPD 移植的报告，旨在提高对 KPD 的认识。KPD 是一种可行、合法且快速发展的模式，可促进与健康、愿意提供 LRD 的供者不匹配的患者进行 LRDRTx。
