Department of Cardiology, Ajou University School of Medicine , Suwon , Korea.
Scand Cardiovasc J. 2013 Oct;47(5):297-302. doi: 10.3109/14017431.2013.824604. Epub 2013 Aug 12.
Epicardial adipose tissue (EAT), deposited around subepicardial coronary vessels, may contribute directly to perivascular inflammation and smooth muscle cell proliferation. This study assessed the relationship between EAT and in-stent restenosis.
Four hundred and seven patients had received successful coronary intervention. EAT thickness was measured by echocardiography. Angiographic follow-up was obtained between 6 months and 2 years. Restenosis was defined as target lesion revascularization (TLR). EAT thickness of patients was compared by TLR controlling for additional well-known predictors of restenosis. The TLR-free survival analysis according to EAT thickness was estimated using the Kaplan-Meier method and the differences between groups were assessed by the log-rank test.
Median EAT thickness was significantly increased in patients undergoing TLR compared with those without restenosis (3.7 vs. 3.0 mm, p = 0.001). EAT thickness was one of the independent factors associated with restenosis (Odds ratio = 1.19, 95% confidence interval = 1.01-1.33, p = 0.007). The TLR-free survival of patients with thick EAT was significantly worse than patients with thin EAT (log-rank p = 0.001).
EAT thickness is related with restenosis and may provide additional information for future restenosis.
心外膜脂肪组织（EAT）沉积于心外膜冠状动脉血管周围，可能直接导致血管周围炎症和平滑肌细胞增殖。本研究评估了 EAT 与支架内再狭窄的关系。
407 例患者成功接受了冠状动脉介入治疗。通过超声心动图测量 EAT 厚度。在 6 个月至 2 年内获得了血管造影随访。再狭窄定义为靶病变血运重建（TLR）。通过控制其他已知的再狭窄预测因素，比较 TLR 患者的 EAT 厚度。采用 Kaplan-Meier 方法估计 EAT 厚度的 TLR 无复发生存分析，并通过对数秩检验评估组间差异。
与无再狭窄患者相比，发生 TLR 的患者 EAT 厚度显著增加（3.7 毫米 vs. 3.0 毫米，p = 0.001）。EAT 厚度是与再狭窄相关的独立因素之一（比值比 = 1.19，95%置信区间 = 1.01-1.33，p = 0.007）。EAT 厚度较厚的患者 TLR 无复发生存明显差于 EAT 厚度较薄的患者（对数秩检验 p = 0.001）。
EAT 厚度与再狭窄有关，可能为未来的再狭窄提供额外的信息。
