一种具有抗肿瘤活性的新型卡瓦酮和antheminone 类似物的合成方法。
A synthetic approach to novel carvotacetone and antheminone analogues with anti-tumour activity.
机构信息
School of Chemistry, University of Manchester, Manchester, UK.
出版信息
Bioorg Med Chem Lett. 2013 Sep 15;23(18):5066-9. doi: 10.1016/j.bmcl.2013.07.041. Epub 2013 Jul 26.
PMID:23937978
Abstract
A synthetic approach to analogues of the terpenoid natural product antheminone A is described which employs (-)-quinic acid as starting material. A key conjugate addition step proved to be unpredictable regarding its stereochemical outcome however the route allowed access to two diastereoisomeric series of compounds. The results of biological assay of the toxicity of the target compounds towards non-small-cell lung cancer cell line A549 are reported.
摘要
描述了一种以（-）-奎宁酸为起始原料合成萜类天然产物antheminone A 类似物的方法。然而，关键的共轭加成步骤在立体化学产物方面的结果难以预测，但该路线允许获得两种非对映异构体系列的化合物。报告了目标化合物对非小细胞肺癌细胞系 A549 的毒性的生物测定结果。
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