Department of Veterinary Clinical Sciences, Royal Veterinary College, University of London, Hawkshead Lane, North Mymms, Hertfordshire AL9 7TA, UK.
Vet J. 2013 Dec;198(3):551-9. doi: 10.1016/j.tvjl.2013.07.014. Epub 2013 Aug 12.
Syringomyelia (SM) is a spinal cord disease that can cause neuropathic pain in dogs. The pathogenesis of SM secondary to Chiari-like malformation (CM) has been the focus of intense research in recent years. The gulf in our understanding of CM/SM in dogs relative to the analogous human condition has progressively narrowed. CM is primarily a disease of abnormal geometric morphometry affecting the caudal cranial fossa and the brain parenchyma contained within it. This review describes how advanced imaging techniques have revealed a series of morphometric abnormalities associated with CM/SM. The series is presented in a logical order to help describe the pathogenesis of CM and the subsequent formation of syringes, with particular reference to the concepts of craniospinal compliance and cerebrospinal fluid pulse pressure timing.
脊髓空洞症（SM）是一种可导致犬类神经性疼痛的脊髓疾病。近年来，Chiari 样畸形（CM）继发 SM 的发病机制一直是研究的重点。与类似的人类疾病相比，我们对犬类 CM/SM 的理解差距逐渐缩小。CM 主要是一种影响颅后窝和其中包含的脑实质的异常几何形态的疾病。本综述描述了先进的成像技术如何揭示与 CM/SM 相关的一系列形态异常。该系列按逻辑顺序呈现，以帮助描述 CM 的发病机制以及随后的空洞形成，特别参考了颅脊髓顺应性和脑脊液脉冲压力时间的概念。
