Department of Studies in Zoology, University of Mysore, Manasagangothri, Mysore 570006, India.
J Biosci. 2013 Sep;38(3):455-60. doi: 10.1007/s12038-013-9348-1.
Sexually dimorphic characters have two-fold complexities in pattern formation as they have to get input from both somatic sex determination as well as the positional determining regulators. Sex comb development in Drosophila requires functions of the somatic sex-determining gene doublesex and the homeotic gene Sex combs reduced. Attempts have not been made to decipher the role of dsx in imparting sexually dimorphic expression of SCR and the differential function of sex-specific variants of dsx products in sex comb development. Our results in this study indicate that male-like pattern of SCR expression is independent of dsx function, and dsx F must be responsible for bringing about dimorphism in SCR expression, whereas dsx M function is required with Scr for the morphogenesis of sex comb.
性二态特征在形态发生方面具有双重复杂性，因为它们必须同时接受体性别的决定以及位置决定调节因子的输入。果蝇的性梳发育需要体细胞性别决定基因 doublesex 和同源基因 Sex combs reduced 的功能。目前尚未尝试破译 dsx 在赋予 SCR 性二态表达中的作用，以及 dsx 产物的性别特异性变体在性梳发育中的不同功能。我们在这项研究中的结果表明，SCR 表达的雄性样模式独立于 dsx 功能，dsx F 必须负责引起 SCR 表达的二态性，而 dsx M 功能则需要与 Scr 一起进行性梳的形态发生。
