Blayo M C, Coudert J, Pocidalo J J
Pflugers Arch. 1975 Apr 29;356(2):159-67. doi: 10.1007/BF00584295.
Samples of cisternal or lumbar cerebrospinal fluid were obtained from 20 young male volunteers born and living at high altitude (3500 to 4800 m). The pH, carbon dioxide and oxygen tensions, and bicarbonate concentration were measured and compared with those in the arterial and jugular venous blood. A consistent difference between the two CSF compartments was noted, particularly a lower pH (0.05), a higher PCO2 (7 Torr), and a lower PO2 (7 Torr) at the lumbar site. Mean bicarbonate concentration was not significantly different at the two sites. The main factor is PCO2, which controls the pH variation. These differences were more marked in high-altitude natives than in man at sea level. The existence of a consistent inhomogeneity of CSF acid-base content emphasizes the inaccuracy of using lumbar CSF pH to estimate the ECF pH as regulator of pulmonary ventilation and determinant of cerebral blood flow.
从20名出生并生活在高海拔地区（3500至4800米）的年轻男性志愿者身上获取了脑池或腰椎脑脊液样本。测量了其pH值、二氧化碳和氧气张力以及碳酸氢盐浓度，并与动脉血和颈静脉血中的相应指标进行了比较。注意到两个脑脊液腔室之间存在一致的差异，尤其是腰椎部位的pH值较低（0.05）、PCO2较高（7托）和PO2较低（7托）。两个部位的平均碳酸氢盐浓度没有显著差异。主要因素是PCO2，它控制着pH值的变化。这些差异在高海拔本地人中比在海平面的人群中更为明显。脑脊液酸碱含量存在一致的不均匀性，这强调了使用腰椎脑脊液pH值来估计作为肺通气调节因子和脑血流量决定因素的细胞外液pH值的不准确性。
