Meng Lei, Wang Jie, Ding Wen-hui, Yang Ying, Qi Li-tong, Huo Yong
Department of Cardiology, Peking University First Hospital, Beijing 100034, China.
Beijing Da Xue Xue Bao Yi Xue Ban. 2013 Aug 18;45(4):630-3.
To investigate the change of plasma osteopontin level during the progress of acute ST-segment elevation myocardial infarction, as well as its association with the left ventricular remodeling and prognosis.
In the study, 61 patients with acute ST-segment elevation myocardial infarction were recruited. Blood samples were taken at admission, on the 3rd day and 7th day of admission, while 63 healthy blood donors were employed as normal controls. There plasma osteopontin levels were measured by ELSIA.
Compared with the normal controls, the plasma osteopontin levels of the patients with acute ST-segment elevation myocardial infarction were significantly higher at admission [(96.51±37.22) μg/L vs. (54.50±28.17) μ g/L, P<0.001], reached the peak value on the 3rd day, and dropped down on the 7th day. The correlation analysis showed that the plasma osteopontin level positively correlated with age and left ventricular end-systolic volume index 3 months after acute myocardial infarction, and negatively correlated with left ventricular ejection fraction 3 months after acute myocardial infarction. The follow-up study found that the plasma osteopontin level did not predict mortality, re-infarction, stroke, revascularization or hospitalization due to heart failure.
In patients with acute ST-segment elevation myocardial infarction, the elevated plasma level of osteopontin might be associated with the left ventricular remodeling.
探讨急性ST段抬高型心肌梗死病程中血浆骨桥蛋白水平的变化及其与左心室重构和预后的关系。
本研究纳入61例急性ST段抬高型心肌梗死患者。于入院时、入院第3天和第7天采集血样，同时选取63名健康献血者作为正常对照。采用酶联免疫吸附测定法（ELISA）检测其血浆骨桥蛋白水平。
与正常对照组相比，急性ST段抬高型心肌梗死患者入院时血浆骨桥蛋白水平显著升高[（96.51±37.22）μg/L对（54.50±28.17）μg/L，P<0.001]，在第3天达到峰值，并于第7天下降。相关性分析显示，血浆骨桥蛋白水平与年龄及急性心肌梗死后3个月的左心室收缩末期容积指数呈正相关，与急性心肌梗死后3个月的左心室射血分数呈负相关。随访研究发现，血浆骨桥蛋白水平不能预测死亡率、再梗死、中风、血管重建或因心力衰竭住院情况。
在急性ST段抬高型心肌梗死患者中，血浆骨桥蛋白水平升高可能与左心室重构有关。
