非侵入性泪膜破裂时间与眼表疾病
Noninvasive tear breakup times and ocular surface disease.
作者信息
Fuller Daniel G, Potts Katlyn, Kim Jeung
机构信息
*OD, FAAO †BS ‡OD, PhD The Eye Center, Southern College of Optometry, Memphis, Tennessee (DGF, JK); and Southern College of Optometry, Memphis, Tennessee (KP).
出版信息
Optom Vis Sci. 2013 Oct;90(10):1086-91. doi: 10.1097/OPX.0000000000000023.
PURPOSE
To investigate the correlation between the Ocular Surface Disease Index (OSDI) Questionnaire and noninvasive tear breakup times (NITBUTs) obtained by the Keratograph 4 (Oculus, Wetzlar, Germany) device.
METHODS
A prospective sequential study of subjects (N = 99) unmatched for sex and without a significant difference in age by sex was performed. Testing included administration of OSDI, followed by Keratograph 4 measurements of the first NITBUT (NITBUT(f)) and average NITBUT (NITBUT(av)).
RESULTS
The NITBUT(f) was significantly shorter than NITBUT(av), as tested by Mann-Whitney statistic (U = 7331.5, <0.0001). The NITBUT(f) and NITBUT(av) demonstrated identical statistically significant Spearman correlations with OSDI (r(s) = -0.20, p = 0.05).
CONCLUSIONS
Ocular Surface Disease Index and NITBUT testing by Keratograph 4 device demonstrate a weak, but statistically significant, negative correlation.
目的
研究眼表疾病指数（OSDI）问卷与通过德国韦茨拉尔奥culus公司的角膜地形图仪4获得的无创泪膜破裂时间（NITBUT）之间的相关性。
方法
对99名性别不匹配且年龄无显著性别差异的受试者进行前瞻性序贯研究。测试包括OSDI问卷的发放，随后通过角膜地形图仪4测量首次NITBUT（NITBUT(f)）和平均NITBUT（NITBUT(av)）。
结果
通过曼-惠特尼统计检验（U = 7331.5，<0.0001），NITBUT(f)显著短于NITBUT(av)。NITBUT(f)和NITBUT(av)与OSDI显示出相同的具有统计学意义的斯皮尔曼相关性（r(s) = -0.20，p = 0.05）。
结论
角膜地形图仪4设备进行的眼表疾病指数和NITBUT测试显示出微弱但具有统计学意义的负相关性。
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