Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong.
Department of Ophthalmology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong.
Clin Exp Ophthalmol. 2018 Aug;46(6):608-615. doi: 10.1111/ceo.13146. Epub 2018 Feb 23.
Diabetes mellitus is known to be associated with dry eye syndrome (DES), but the effects of long-term glycaemic control on tear film metrics and dry eye symptoms are not known in the Chinese population.
To evaluate tear film stability and dry eye symptoms and their associations with systemic risk factors in Chinese patients with type 2 diabetes mellitus (T2DM).
Cross-sectional study set at the Lo Fong Siu Po Eye Centre (Grantham Hospital), Hong Kong.
A total of 80 Chinese participants, aged 18 or above, with T2DM recruited from the specialist outpatient setting were included.
The Oculus Keratograph 5M (Oculus Inc., Wetzlar, Germany) was used to measure the non-invasive tear break-up time (NITBUT). Ocular symptoms were evaluated using the Ocular Surface Disease Index (OSDI). The association between OSDI, NITBUT and metabolic parameters relating to diabetes were evaluated using multiple linear regression.
The associations between long-term glycaemic control and NITBUT and OSDI scores.
Stepwise multiple linear regression analysis revealed glycated haemoglobin to be the only significant independent variable for NITBUT (R = 0.099, P = 0.014) and OSDI (R = 0.062, P = 0.044) after controlling for potential confounders. The age-adjusted prevalence of DES was 20% (95% confidence interval: 11-30%) in the Chinese T2DM population. The odds of DES for increasing percentage of glycated haemoglobin was 1.49 (95% confidence interval: 1.03-2.17, P = 0.04).
Our findings highlight the importance of good glycaemic control as a modifiable risk factor for both dry eye symptoms and tear film instability in patients with T2DM.
已知糖尿病与干眼综合征（DES）有关，但在中国人群中，长期血糖控制对泪膜参数和干眼症状的影响尚不清楚。
评估泪膜稳定性和干眼症状及其与 2 型糖尿病（T2DM）中国患者系统危险因素的关系。
香港乐丰兆博眼科中心（格兰瑟姆医院）的横断面研究。
共纳入 80 名年龄在 18 岁及以上的来自专科门诊的 T2DM 中国患者。
使用 Oculus Keratograph 5M（Oculus Inc.，德国威茨拉尔）测量非侵入性泪膜破裂时间（NITBUT）。使用眼表面疾病指数（OSDI）评估眼部症状。使用多元线性回归评估 OSDI、NITBUT 与糖尿病相关代谢参数之间的关系。
长期血糖控制与 NITBUT 和 OSDI 评分之间的关系。
逐步多元线性回归分析显示，糖化血红蛋白是 NITBUT（R=0.099，P=0.014）和 OSDI（R=0.062，P=0.044）的唯一显著独立变量，在控制了潜在的混杂因素后。年龄调整后的 DES 在 T2DM 中国人群中的患病率为 20%（95%置信区间：11%-30%）。糖化血红蛋白每增加 1%，DES 的几率为 1.49（95%置信区间：1.03-2.17，P=0.04）。
我们的研究结果强调了良好的血糖控制作为 T2DM 患者干眼症状和泪膜不稳定的可改变危险因素的重要性。
