影响β-肾上腺素能受体的药物的中枢作用。IV. 脑室内注射影响β-肾上腺素能受体的药物对大鼠血压的影响。
The central action of drugs affecting beta-adrenergic receptor. IV. The influence of intraventricularly administered drugs affecting beta-adrenergic receptor on blood pressure in rats.
作者信息
Kleinrok Z, Ksiazek A
出版信息
Pol J Pharmacol Pharm. 1975 Apr-Jun;27(2):177-82.
PMID:239397
Abstract
Isoprenaline, propranolol, alprenol and sotalol administered intraventricularly (ivc) to anaesthetized rats induce hypotension. Propanolol and alprenolol given ivc to rats pretreated with isoprenaline increase blood pressure up to the values equal to those, previous to isoprenaline administration; another isoprenaline dose acts slightly hypotensively.
摘要
将异丙肾上腺素、普萘洛尔、阿普洛尔和索他洛尔经脑室注射（ivc）给麻醉大鼠会导致低血压。给用异丙肾上腺素预处理过的大鼠经脑室注射普萘洛尔和阿普洛尔，可使血压升高至与注射异丙肾上腺素之前相等的值；再注射一剂异丙肾上腺素则会产生轻微的降压作用。
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