在尼日利亚东南部，大规模分发长效驱虫蚊帐可阻断淋巴丝虫病传播。
Community-wide distribution of long-lasting insecticidal nets can halt transmission of lymphatic filariasis in southeastern Nigeria.
机构信息
Malaria, River Blindness, Lymphatic Filariasis, and Schistosomiasis Programs, The Carter Center, 453 Freedom Parkway, Atlanta, GA 30307, USA.
出版信息
Am J Trop Med Hyg. 2013 Sep;89(3):578-87. doi: 10.4269/ajtmh.12-0775. Epub 2013 Aug 12.
Abstract
Lymphatic filariasis (LF) in rural southeastern Nigeria is transmitted mainly by Anopheles spp. mosquitoes. Potential coinfection with Loa loa in this area has prevented use of ivermectin in the mass drug administration (MDA) strategy for LF elimination because of potential severe adverse L. loa-related reactions. This study determined if long-lasting insecticidal net (LLIN) distribution programs for malaria would interrupt LF transmission in such areas, without need for MDA. Monthly entomologic monitoring was conducted in sentinel villages before and after LLIN distribution to all households and all age groups (full coverage) in two districts, and to pregnant women and children less than five years of age in the other two districts. No change in human LF microfilaremia prevalence was observed, but mosquito studies showed a statistically significant decrease in LF infection and infectivity with full-coverage LLIN distribution. We conclude that LF transmission can be halted in southeastern Nigeria by full-coverage LLIN distribution, without MDA.
摘要
淋巴丝虫病（LF）在尼日利亚东南部农村地区主要通过按蚊传播。由于潜在的严重与罗阿罗阿相关的不良反应，该地区的潜在合并感染可能会阻止在大规模药物管理（MDA）策略中使用伊维菌素来消除 LF。本研究确定在无需 MDA 的情况下，长效驱虫蚊帐（LLIN）分发计划是否会中断此类地区的 LF 传播。在两个区向所有家庭和所有年龄组（全覆盖）以及在另外两个区向孕妇和五岁以下儿童分发 LLIN 前后，在哨点村庄每月进行昆虫学监测。未观察到人类 LF 微丝蚴患病率的变化，但蚊子研究表明，全覆盖 LLIN 分发可显著降低 LF 感染率和感染力。我们的结论是，在尼日利亚东南部，通过全覆盖 LLIN 分发可以阻断 LF 传播，而无需 MDA。
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