Department of Companion Animals and Equids, Faculty of Veterinary Medicine, B41, Equine Clinic, University of Liège, Sart Tilman, Liège 4000, Belgium.
Vet Rec. 2013 Sep 21;173(11):267. doi: 10.1136/vr.101503. Epub 2013 Aug 12.
The objectives of this study were to describe and relate perioperative changes in blood leukocyte counts to the outcome of surgical colic horses, determine a cut-off value in the early postoperative period to obtain an indicator of the outcome, and compare the obtained value to a validation population of horses. Fifty-three horses undergoing colic surgery were included in the descriptive part of the study. Total leukocyte counts were performed before, during and serially after surgery. A receiver operating characteristic analysis was performed on the leukocyte counts of 45 of these horses to determine a cut-off value for the outcome. The results obtained were validated on a second set of 50 horses that underwent colic surgery in similar conditions. The kinetics of blood leukocytes in survivors was higher than in non-survivors during the first days. Non-survivor horses were more likely to have at least one blood leukocyte count ≤ 3.9 × 10(3)/mm(3) between 28 and 60 hours after surgery than survivor horses. This cut-off value was confirmed in the validation population. These results suggest that routine values of blood leukocyte counts can be used as an additional prognostic indicator after colic surgery alongside other predictors previously associated with the outcome.
本研究的目的在于描述和分析围手术期血液白细胞计数的变化与手术性腹痛马预后的关系，确定术后早期的一个截断值，以获得预后的指标，并将获得的值与马的验证人群进行比较。本研究的描述性部分纳入了 53 匹接受腹痛手术的马。在手术前、手术中和手术后连续进行总白细胞计数。对其中 45 匹马的白细胞计数进行了受试者工作特征分析，以确定预后的截断值。在接受类似条件下腹痛手术的第二组 50 匹马中对获得的结果进行了验证。在最初几天，存活马匹的血液白细胞动力学高于非存活马匹。与存活马匹相比，非存活马匹在术后 28 至 60 小时之间至少有一次白细胞计数≤3.9×10(3)/mm(3)的可能性更高。该截断值在验证人群中得到了证实。这些结果表明，在接受腹痛手术后，除了与预后相关的其他预测因素外，常规的血液白细胞计数值可作为附加的预后指标。
