SAA1 基因多态性与非糖尿病患者的血浆葡萄糖浓度有关。

SAA1 genetic polymorphisms are associated with plasma glucose concentration in non-diabetic subjects.

出版信息

Clin Chem Lab Med. 2013 Dec;51(12):2331-4. doi: 10.1515/cclm-2013-0097.

DOI:10.1515/cclm-2013-0097

Abstract

BACKGROUND

Serum amyloid A (SAA) was reported to be associated with insulin resistance and type-2 diabetes. The present study aimed to investigate the association of SAA genetic polymorphisms with plasma glucose levels in non-diabetic subjects.

METHODS

All participants (n=1220) were selected from subjects participating in the Cardiovascular Risk Survey (CRS) study. Five single-nucleotide polymorphisms (SNPs) (rs2229338, rs12218, rs4638289, rs7131332 and rs11603089) of SAA gene were genotyped using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) analysis.

RESULTS

In the present study, we found rs2229338, rs4638289 and rs12218 were significantly associated with plasma glucose levels in a dominate model, recessive model or additive model before and after multivariate adjustment (all p<0.05). These associations were not found in rs7131332 and rs11603089 before and after adjustment of key co-variants.

CONCLUSIONS

The genetic polymorphisms of SAA1 were associated with plasma glucose levels in non-diabetic subjects.

摘要

背景

血清淀粉样蛋白 A（SAA）与胰岛素抵抗和 2 型糖尿病有关。本研究旨在探讨 SAA 基因多态性与非糖尿病患者血浆葡萄糖水平的关系。

方法

所有参与者（n=1220）均选自心血管风险调查（CRS）研究中的受试者。使用聚合酶链反应（PCR）-限制性片段长度多态性（RFLP）分析对 SAA 基因的 5 个单核苷酸多态性（SNP）（rs2229338、rs12218、rs4638289、rs7131332 和 rs11603089）进行基因分型。